Fofana's inclusion in the starting XI is a significant moment as it marks his first appearance in 448 days.
Meanwhile, City boss Pep Guardiola has handed Savinho a Premier League debut after his summer arrival from Troyes.
Chelsea: Sanchez: Gusto, Fofana, Colwill, Cucurella; Lavia, Caicedo; Palmer, Fernandez (C), Nkunku; Jackson
Chelsea substitutes: Jorgensen, Tosin, Badiashile, Veiga, Dewsbury-Hall, Mudryk, Neto, Madueke, Guiu
Man City: Ederson, Lewis, Akanji, Dias, Gvardiol, Kovacic, De Bruyne (C), Bernardo, Doku, Savinho, Haaland
Man City substitutes: Ortega Moreno, Walker, Stones, Ake, Grealish, Nunes, Foden, O'Reilly, McAtee